By 2033, advancements in geroscience could achieve “longevity escape velocity,” enabling significant extensions to human lifespan. Concurrently, autonomous Agentic AI systems are expected to revolutionize productivity while displacing 14-18% of the global workforce, impacting approximately 300 million jobs globally. These changes occur against a backdrop of resource scarcity, as humanity’s extraction of 170 billion tonnes of virgin materials annually by 2050 necessitates urgent improvements in circularity, with the current rate standing at just 8.6%. Together, these trends signal a future shaped by extended lifespans, transformative AI innovation, and the imperative for sustainable practices.

Three critical sciences—data science, geroscience, and climate science—will redefine societal norms in the coming decade. Data science will drive the need for shorter career cycles and lifelong learning, while geroscience extends human lifespans and shifts retirement dynamics, potentially eliminating traditional milestones like the “empty nest.” Climate science must address the challenge of resource renewal amidst accelerated extraction rates. Emerging technologies, including AI-powered diagnostics, genetic engineering, and tissue regeneration, will accelerate progress in healthcare and productivity. The next phase of AI development envisions autonomous systems capable of creating agents to perform complex tasks, highlighting the transition from generative AI to fully autonomous functionalities.

China is poised as a global leader in AI, housing 26% of the world’s elite AI talent and fostering innovation through significant investments and regulatory advancements. AI integration is rapidly reshaping industries, with virtual assistants, autonomous robotics, and digital twins driving the adoption of intelligent systems across various sectors. To navigate these transformative changes, adaptability through multidisciplinary education, active aging, and progressive policy reforms will be essential. This era presents immense opportunities and challenges, demanding collaboration and innovation to realize its full potential.